ChloroquineV1, Main, Exploration, bibRecord, 000052

Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis

Identifieur interne : 000052 ( Main/Exploration ); précédent : 000051; suivant : 000053

Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis

Auteurs : Nan Zhang [République populaire de Chine] ; Fu Peng [République populaire de Chine] ; Yujia Wang [République populaire de Chine] ; Li Yang [République populaire de Chine] ; Fengbo Wu [République populaire de Chine] ; Xiaoyun Wang [République populaire de Chine] ; Cui Ye [République populaire de Chine] ; Bo Han [République populaire de Chine] ; Gu He [République populaire de Chine]

Source :

International Journal of Biological Sciences [ 1449-2288 ] ; 2020.

RBID : PMC:6930377

Abstract

Colorectal carcinoma (CRC) is the third most common malignant tumor pathology worldwide. Despite progress in surgical procedures and therapy options, CRC is still a considerable cause of cancer-related mortality. In this study, we tested the antitumor effects of shikonin in CRC and tried to identify its potential mechanism. The potential target, molecular mechanism as well as in vitro and in vivo antitumor effects of shikonin in CRC cells were determined by an integrative protocol including quantitative proteomics, RT-PCR, western blotting, RNA interference and overexpression, apoptosis and autophagy assays, etc. Galectin-1 was a potential target of shikonin from the iTRAQ-based proteomic analysis in shikonin-treated SW620 cell. The overexpression and RNA silencing of galectin-1 in two CRC cells suggested that the shikonin sensitivity was correlation to galectin-1 levels. The ROS accumulation induced by shikonin was important to the formation of galectin-1 dimers. Dimer galectin-1 was found to be associated with the activation of JNK and downstream apoptosis or autophagy. Moreover, through functional in vitro studies, we showed that differences in galectin-1 level affected tumor cell proliferation, migration, and invasion. In summary, shikonin induced CRC cells apoptosis and autophagy by targeting galectin-1 and JNK signaling pathway both in vitro and in vivo, which suggested a potential novel therapy target for CRC.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930377

DOI: 10.7150/ijbs.36955
PubMed: 31892852
PubMed Central: 6930377

Affiliations:

République populaire de Chine

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Colorectal carcinoma (CRC) is the third most common malignant tumor pathology worldwide. Despite progress in surgical procedures and therapy options, CRC is still a considerable cause of cancer-related mortality. In this study, we tested the antitumor effects of shikonin in CRC and tried to identify its potential mechanism. The potential target, molecular mechanism as well as <italic>in vitro</italic>
 and <italic>in vivo</italic>
 antitumor effects of shikonin in CRC cells were determined by an integrative protocol including quantitative proteomics, RT-PCR, western blotting, RNA interference and overexpression, apoptosis and autophagy assays, etc. Galectin-1 was a potential target of shikonin from the iTRAQ-based proteomic analysis in shikonin-treated SW620 cell. The overexpression and RNA silencing of galectin-1 in two CRC cells suggested that the shikonin sensitivity was correlation to galectin-1 levels. The ROS accumulation induced by shikonin was important to the formation of galectin-1 dimers. Dimer galectin-1 was found to be associated with the activation of JNK and downstream apoptosis or autophagy. Moreover, through functional <italic>in vitro</italic>
 studies, we showed that differences in galectin-1 level affected tumor cell proliferation, migration, and invasion. In summary, shikonin induced CRC cells apoptosis and autophagy by targeting galectin-1 and JNK signaling pathway both <italic>in vitro</italic>
 and <italic>in vivo</italic>
, which suggested a potential novel therapy target for CRC.</p>
</div>
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Serveur d'exploration Chloroquine

Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis

Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis

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